Oxidized LDL

The prime focus of most drug research concerning cardiovascular disease has been about lowering cholesterol levels, and that is about all you will hear in their ads on television. However, thousands of studies are now showing how oxidized LDL is much more dangerous and promotes virtually every stage of atherosclerosis; therefore, in addition to lowering its level, it is just as important to keep your LDL cholesterol from becoming oxidized. LDL cholesterol can become oxidized by free radicals. Oxidized cholesterol is more prone to stick to arterial walls and form foam cells that eventually form plaque. Commercial tests are not yet available to measure oxidized cholesterol at affordable prices. Since there is no economical test to determine the degree to which LDL cholesterol is oxidizing in your body, it is bet to quench inflammation, take antioxidants, lower Apo B (apolipoprotein B) levels, and take supplements to reduce small LDL particles.

For example, the higher the calorie, sugar, and fat content of each of your meals, the greater you will experience what doctors call postprandial oxidative stress after you have finished eating. It is an oxidation process. So eating a Mediterranean diet wins again. You can also drink water with lemon or lime, green or black tea, or 2 ounces pomegranate juice with your meals to reduce this oxidation process.

It is also recommended that you take the following in supplement form if you are not getting these nutrients to lower oxidized cholesterol:

• Gamma tocopherol
• Pomegranate juice
• Ubiquinol (CoQ10)
• Grape seed and/or pine bark extracts
• Theaflavin

Apolipoprotein B

Apo B is a measurement of the number of LDL (bad cholesterol) particles in the blood. It is the protein portion of the low-density lipoprotein and transfers cholesterol from the lipoprotein either to the cells to be used or to the liver to be excreted. If the amount of Apo B present is in proportion to the amount needed by the cells, then no problem occurs. However, if you have an excess of Apo B, the excess Apo B will usually deposit cholesterol in arterial walls. Apo B determines whether the cholesterol is used correctly, it determines if cholesterol ends up as plaque. It is believed that LDL particle numbers may predict coronary artery disease risk better than LDL levels. Apo B is mainly genetically determined. Having a large number of LDL particles has been shown to increase heart attack risk even when the total LDL is normal or low and that this measurement is among the most powerful tools for predicting an ischemic event.

To determine the number of LDL particles, it is possible to count apolipoprotein B (Apo B) particles, because Apo B is the major protein particle of an LDL cluster, and each LDL cluster will have only one. It is possible to have an LDL number of 80 (normal), for instance, but an Apo B count of either 50 (normal) or 130 (elevated). (Note that a normal Apo B level would be anything below 60). Unfortunately, a low LDL amount but a high Apo B count is fairly common and increases your risk of cardiovascular disease.

Proper diet, regular exercise, and supplementation are effective in reducing your Apo B level. Avoiding trans fats and reducing saturated fats in your diet are also extremely important in lowering Apo B. below are supplements to lower Apo B:

• Niacin
• Red yeast rice
• Sytrinol
• Pantethine

LDL particle size:

Small LDL particles are far more atherogenic (plaque forming) because they are 40 percent more likely to get stuck in artery walls and form plaque. Studies have shown small LDL triples the likelihood of developing coronary plaque. Small LDL also shows a tendency toward insulin resistance and thus an increased risk of diabetes, especially if you are overweight or obese. Other research has shown that if you have small LDL particles and high C – reactive protein (CRP) levels, your chances of a heart attack are six times higher than normal.

The best way to keep LDL particle size larger and safer is by maintaining a healthy weight. Taking 1,500-3,000 mg of niacin a day (or as directed by your doctor) can also help control LDL size. Research is showing niacin may be the most effective nutrient to take to help eliminate small LDL. It is also best to eat foods that have a low glycemic index (GI) number and thus release sugars more slowly after eating. Note that stain drugs have only a minimal to no effect on LDL particle size. Taking soluble fiber supplements with your other foods can also help in promoting larger LDL particles, as can making sure you are getting enough omega-3 fatty acids and getting regular exercise.

Ascorbate (vitamin C) is a highly potent aqueous-phase antioxidant in plasma, which has been shown in vitro to retard LDL oxidation. USANA Vitamins Supplements Booster C 600™ has a special blend of immunity-supporting ingredients. It contains zinc, echinacea, and elderberry and includes USANA’s own proprietary vitamin C supplement Poly C as well. Booster C 600 is also the perfect seasonal companion to USANA’s other supplements that support immunity health: USANA Proflavanol® C100, USANA® Probiotic, Pure Rest™, and USANA’s Vitamin D supplement.